Immune Health

How Cellular Cleanup Boosts Your Immune System

Q: How exactly does Cellitas work at the cellular level?

Cellitas works by increasing autophagy, your body's natural cellular recycling process that boosts energy levels and allows for faster cell renewal. Our patent-pending formula combines two polyamines (spermidine and spermine) and one amino acid (arginine) with BB12™ probiotic to enhance this process. Autophagy removes damaged cellular components and recycles them into building blocks that can be used for fuel or cell duplication, maintaining cellular integrity and function throughout life.

Q: What makes your formula different from other spermidine supplements?

Unlike standard spermidine supplements, Cellitas features a patent-pending combination of two polyamines, an amino acid, a medium chain triglyceride (MCT), plus the BB12™ probiotic. This unique formulation creates a synergistic effect that extends the release of spermidine available for cellular absorption. This helps maintain higher levels of autophagy throughout the day. Our approach activates multiple cellular pathways simultaneously rather than focusing on a single mechanism.

Q: How soon might I notice results from taking Cellitas?

While cellular renewal begins immediately, most people report noticeable improvements in energy and vitality within 2-4 weeks of consistent use. Since Cellitas works at the fundamental cellular level, benefits accumulate over time until autophagy reaches a higher plateau.

Q: Are there any dietary recommendations to maximize benefits?

Cellitas works effectively on its own, but its benefits can be complemented by a healthy diet, regular exercise, quality sleep, and stress management. Notice that a normal western diet will provide you with 6-16mg of spermidine per day. We recommend taking Cellitas daily, preferably in the morning with or without food, as part of your overall wellness routine.

Q: Is Cellitas suitable for all adults regardless of age?

Cellitas is designed primarily for adults 45+ who are seeking to maintain their vitality and health as they age. That said, the cellular processes Cellitas supports are beneficial for adults of all ages. As with any supplement, we recommend consulting with your healthcare provider before beginning, especially if you have existing health conditions.

Q: Can Cellitas be taken with other supplements or medications?

Cellitas is designed with high-quality, natural ingredients that generally work well alongside other supplements. As all polyamines are an integral part of any cell, there should not be any abnormal interaction with other drugs and supplements. However, as with any supplement, we recommend consulting with your healthcare provider before adding Cellitas to your regimen, especially if you're taking prescription medications. Your healthcare provider can help determine if there are any specific interactions relevant to your individual health situation.

Q: How do I take Cellitas?

Cellitas™ comes in convenient daily sachets that can be mixed with water or your favorite beverage. Simply tear open one packet each morning and stir the contents into at least 8oz of liquid. The premium powder formula dissolves easily and has a mild, pleasant taste. Each box contains a full 30-day supply. We recommend not using hot beverages, as high temperatures could inhibit or destroy the probiotic.

Q: Is Cellitas safe to take long-term?

Yes. Our clinical trials showed no serious adverse events or reactions. Spermidine is naturally found in foods like mushrooms, mature cheeses, and whole grains, making it a natural part of the human diet. It also part of any of our cells. Unlike other longevity supplements, Cellitas™ contains ingredients that work with your body's natural processes. As with any supplement, we recommend consulting with your healthcare provider before beginning, particularly if you have existing health conditions.

Q: How does Cellitas compare to other longevity supplements like NAD+ boosters?

You will pay the shipping rate you paid for at checkout. We do not charge additional shipping for personalized items. However, if other item(s) were included in your cart, we will try to ship them at the same time as your personalized item(s). If there will be a long delay, we will likely ship your non-personalized items first. If you have any questions about shipping, please contact customer support.

Q: How can I check the status of my order?

Unlike NAD+ supplements (such as NMN or NR) that have shown limited absorption and negligible benefits in human studies, Cellitas™ has been clinically shown to increase autophagy with no serious adverse events. Independent research has not validated these benefits at the cellular levels for NAD+ precursors in healthy individuals. Our clinical trial demonstrated a significant improvement in a key autophagy marker (Beclin-1) that plays a key role in cellular health.

Nov 12, 2025

Your immune system is like a highly trained army, constantly patrolling your body and defending against threats. But what if this army's weapons were dull, their equipment outdated?

Your cells' natural housekeeping process—autophagy—plays a crucial role in keeping your immune defenses sharp and ready for action.

What Is Autophagy And Why Does Your Immune System Need It?

Autophagy literally means "self-eating," but it's actually your cells' sophisticated recycling program. Think of it as a quality control system that identifies damaged proteins, worn-out organelles, and cellular debris, then breaks them down and repurposes the materials for new cellular components.

This cleanup process is essential for your immune system. Immune cells are among the most metabolically active in your body, constantly producing proteins, generating energy, and responding to threats. Without efficient autophagy, these cells accumulate damaged components that impair their function.

How Does Autophagy Enhancement Strengthen Immune Function?

Research demonstrates several key ways that autophagy supports immune health.

Enhanced Cell Survival and Function

Largely pre-clincal studies show that when autophagy is activated, immune cells experience reduced apoptosis (cell death) and improved viability. In one clinical trial examining 72-hour intensive fasting, researchers found a significant increase in the percentage of live CD45+ leukocytes, with reduced markers of cell death.

Improved Neutrophil Activity

Neutrophils are the immune system's first responders to bacterial infections. Research in pre-clinical models shows that enhanced autophagy supports neutrophil homeostasis, survival, and functionality. This can reduce neutrophils' effectiveness and how they release their arsenal against infections. All proteins involved in neutrophil degranulation showed significant upregulation when autophagy was enhanced.

Better Cytokine Production

Cytokines are signaling molecules that coordinate immune responses. Enhanced autophagy influences cytokine production and secretion, improving communication among innate and adaptive immune cells (e.g., macrophages, dendritic cells, neutrophils, NK cells).

What Triggers Autophagy In Immune Cells?

Several factors can activate your cellular cleanup system.

Nutrient deprivation, such as during short-term fasting or caloric restriction, triggers autophagy through multiple signaling pathways. When cellular energy (ATP) levels decline, AMP-activated protein kinase (AMPK) becomes activated, inhibiting mTOR signaling and initiating autophagy.
Exercise similarly induces mild cellular stress that activates autophagy pathways, helping immune cells maintain optimal metabolic and functional balance.
Naturally occurring polyamines such as spermidine and spermine also promote autophagy directly; spermidine enhances autophagosome formation via the polyamine pathway, complementing spermine’s regulatory effects.

Some of these mechanisms have been demonstrated primarily in pre-clinical models, and ongoing work continues to explore their translational potential.

How Does Fasting Impact Immune Cell Behavior?

Recent studies do reveal fascinating insights about how fasting affects immune function. Keep in mind that longer-term human studies are limited, though.

Monocyte Migration

During fasting, circulating monocytes migrate back to the bone marrow, where they enter a hibernation-like state, conserving energy. Upon refeeding, these cells return to circulation with altered function that can affect immune responses.

Timing Matters

Short-term intensive fasting (72 hours) enhances immune function, particularly innate immunity, while prolonged fasting may have different effects. The research shows improved neutrophil activation and increased immune protein production within normal ranges.

Balanced Approach

While fasting can boost immune function, the immune system requires careful balance. Excessive fasting may compromise immune responses, while moderate approaches appear beneficial.

What Are The Practical Implications For Immune Health?

Understanding the autophagy-immune connection offers several actionable insights:

Nutrition Timing: Strategic periods of nutrient restriction can enhance immune function, but should be balanced with adequate nutrition during refeeding periods
Compound Support: Research shows that specific autophagy-enhancing compounds like spermidine, combined with supportive nutrients and probiotics, can help maintain optimal immune cell cleanup.
Lifestyle Factors: Regular exercise, adequate sleep, and stress management all support healthy autophagy function and immune resilience.
Individual Variation: Age, health status, and genetic factors influence how individuals respond to autophagy enhancement, making personalized approaches important.

What Does This Mean For Your Daily Health Strategy?

The connection between cellular cleanup and immune function suggests that supporting autophagy should be part of a comprehensive health approach. However, this doesn't mean extreme measures are necessary or advisable.

Research indicates that occasional short-term fasting, combined with compounds that support autophagy and cellular renewal, may help maintain optimal immune function. The key appears to be supporting your body's natural processes rather than forcing dramatic changes.

Your immune system's effectiveness depends largely on the health of individual immune cells. When these cells can efficiently clear out damaged components and maintain optimal function through enhanced autophagy, your entire immune defense network operates more effectively.

This cellular approach to immune health offers a foundational strategy that works alongside traditional immune support methods, providing comprehensive protection from the inside out.

Learn more about your cellular health today with Cellitas.

Blog Team